THE SCAFFOLD PROTEIN NDE1 SAFEGUARDS THE BRAIN GENOME DURING S PHASE OF EARLY NEURAL PROGENITOR DIFFERENTIATION

The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation

Successfully completing the S phase of each cell cycle ensures genome integrity.Impediment of DNA replication can lead to DNA damage and genomic HR Board Receiver disorders.In this study, we show a novel function for NDE1, whose mutations cause brain developmental disorders, in safeguarding the genome through S phase during early steps of neural pr

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